Inside the cell
Mitochondrial science
Mitophagy, NAD+ metabolism, and the difference between a mechanism and a measurable benefit.
- Mitophagy and quality control
- NAD+ metabolism
- Mitochondrial density
- Biomarker versus outcome
Lead review
Mitophagy is not the same as more energy
The most successful marketing idea in the longevity category rests on collapsing two different processes into one word. Separating them changes what you should expect.
Beat
Performance science
Unit
The individual trial
Comparator
Training, always
Policy
Nothing sponsored
What we cover
Three questions: what is happening inside the cell, what is happening inside the skull, and what happens when you compare either against training.
Above the neck
Cognition and nootropics
Cognitive supplements, the attribution problem in stacks, and what a clinically studied label really means.
- Creatine and cognition
- Multi-ingredient stacks
- Caffeine and L-theanine
- Reading efficacy claims
The comparator
Training for healthspan
Cardiorespiratory fitness, resistance training, intensity distribution, and the evidence supplements get measured against.
- Cardiorespiratory fitness
- Resistance training
- Intensity distribution
- Injury and repair claims
Recently reviewed
Each piece gets re-read when new trial data lands. Filter by section to see what changed.
Mitochondrial scienceMitophagy is not the same as more energy
The most successful marketing idea in the longevity category rests on collapsing two different processes into one word. Separating them changes what you should expect.
Cognition and nootropicsCreatine's cognitive results are real, small, and mostly about sleep debt
A 2026 trial found a single dose reduced cognitive deterioration during sleep deprivation. That is a narrower and more interesting finding than the coverage suggested.
Training for healthspanVO2 max is the healthspan metric with the least argument attached
Among everything measured in this field, cardiorespiratory fitness has the most consistent relationship with outcomes and the fewest people disputing it.
Mitochondrial scienceUrolithin A's muscle results, read carefully
The trials are real, the direction is consistent, and the effect sizes are modest in populations that are not you if you are 28 and training four times a week.
Cognition and nootropicsThe six-ingredient nootropic problem
Stacks are designed so that no individual ingredient can be evaluated. That is convenient for the seller and useless for the buyer.
Mitochondrial scienceNAD+ precursors raise the marker. The function is the open question.
Twenty-five randomised trials establish that oral dosing works pharmacologically. Whether that produces something people notice remains unresolved.
What we are working on
Stories in progress, with roughly where they stand. Vote to tell the desk what to prioritise.
Publishing soon
Lactate, zone boundaries, and why your threshold estimate is probably wrong
In review
Muscle protein synthesis is a proxy, not an outcome
Drafting
Blood flow restriction training: strong evidence, awkward practicalities
Researching
Do longevity compounds blunt training adaptation
Write for us
We publish exercise physiologists, pharmacologists, sports scientists, and clinicians. Every claim gets checked against the trial that produced it.
Trial reads
Take one study and work through design, population, dose, duration, and what the effect size means in practice.
Mechanism explainers
Cellular and systemic physiology written for people who want the actual pathway, not an analogy about batteries.
Training science
Programming, adaptation, and the intervention every supplement is implicitly being compared against.
What we will and will not publish
- Claims must trace to a named trial, review, registry entry, or regulator document.
- Pieces run 1,200 to 2,500 words and say plainly where the evidence is thin.
- No paid placements, no affiliate copy dressed as reporting, no brand-supplied claims.
- Any commercial relationship, including free product, is disclosed in the byline.
Editors' picks
Longer pieces we keep sending people back to.
Mitochondrial scienceMitophagy is not the same as more energy
The most successful marketing idea in the longevity category rests on collapsing two different processes into one word. Separating them changes what you should expect.
Cognition and nootropicsCreatine's cognitive results are real, small, and mostly about sleep debt
A 2026 trial found a single dose reduced cognitive deterioration during sleep deprivation. That is a narrower and more interesting finding than the coverage suggested.
Training for healthspanVO2 max is the healthspan metric with the least argument attached
Among everything measured in this field, cardiorespiratory fitness has the most consistent relationship with outcomes and the fewest people disputing it.